Today, our paper “Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq” has been published as a Letter in Nature Biotechnology. My experimental co-authors developed a technique to perform patch-clamp recordings in cortical neurons followed by single-cell RNA sequencing. As a proof of principle, we show that physiological and anatomical cell types as well as physiological properties can be recovered based on the transcriptomes of individual neurons. Interestingly, a very related technique was independently developed by another lab – their paper is published alongside with ours. These techniques allow studying cell types from the genetic to the functional level, opening exciting avenues for future work!
The paper’s altmetric score can be found here.